from: Birkhauser
Regular marked price: $169.00Discount Price: $71.96
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Type of bind: Kindle Edition
Dewey Decimal Number: 616.99449061
Format: Kindle Book
Label: Birkhauser
Manufacturer: Birkhauser
Quantity: 1
Page Count: 182
Printing Date: December 20, 1990
Publishing house: Birkhauser
Sale Popularity Level: 118025
Studio: Birkhauser
Editor's Notes and Comments:
Product Description:
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence its trivial name of 'aromatase'). Whilst the very first aromatase inhibitors showed therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, subsequently, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest these agents will become the cornerstones of future endocrine therapy.
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