Books : Concise Guide to Drug Interaction Principles for Medical Practice: Cytochrome P450s, Ugts, P-Glycoproteins (Concise Guides)
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Type of bind: Paperback
Dewey Decimal Number: 615.788
EAN num: 9781585621118
ISBN number: 1585621110
Label: American Psychiatric Publishing, Ltd.
Manufacturer: American Psychiatric Publishing, Ltd.
Quantity: 1
Page Count: 525
Printing Date: 2003-05
Publishing house: American Psychiatric Publishing, Ltd.
Sale Popularity Level: 943836
Studio: American Psychiatric Publishing, Ltd.
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Editor's Notes and Comments:
Product Description:
The long-awaited second edition of this best-selling Concise Guide is here. Like the very first edition of this unique pocket reference, the second edition is written expressly for clinicians. With four new contributors, this edition includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive website references. Brand-new chapters discuss P-glycoproteins, 'minor' cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, drug interaction assessment and prescribing guidelines, and medicolegal issues.
Following Part I, a succinct review of pharmacology, Part II contains pertinent tables, short reviews, and carefully chosen clinical and research illustrations (with case vignettes) for each P450 enzyme. In Part III, unique to this guide, the drugs used commonly in nonpsychiatric medicine that have clinically significant pharmacokinetic phase I, phase II, or P-glycoprotein drug interactions are arranged by specialty and listed in tables. Part IV focuses on practical matters, with chapters on drug interaction assessment and prescribing guidelines, medicolegal issues, and review and retrieval of the literature.
To enhance clinicians' use of this guide as a quick reference, the authors provide a pocket guide to the most common and potent inhibitors and inducers of drug metabolism, by enzyme system and by medical specialty.
Designed to enable psychiatrists to develop individualized tables and references for their own practices, this concise 'how-to' guide will prove indispensable for students and practitioners in psychiatric (especially in complicated medical/surgical settings, such as geriatrics) and nonpsychiatric (primary care, family practice, internal medicine, and obstetrics/gynecology) specialties alike.
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Rated by buyers -
I wrote a review for the very first edition of this book and thought it was excellent. This edition is even better and as far as I can tell is state of the art even yesterday in researching drug interactions.
The authors provide excellent summaries of drug metabolism in general and specific chapters on cytochromes, phase II metabolism, and P-glycoproteins. The chapters are logically organized and contain many case examples. As an example the cytochrome chapters describe the function, localization, inhibitors and inducers of each enzyme.
Rather than detail the specifics - I can tell you how a clinician treating complex problems might use this book. Medical care has become increasingly complex. It is common to treat people who are taking various combinations of maintenance medications like antihypertensives and cholesterol lowering drugs. Those drugs may be combined with medications to treat diabetes or other chronic medical disorders. The introduction of one or more psychiatric medications can lead to problems at the pharmacokinetic level.
A rapid check using computerized drug interaction programs or lists for specific conditions like prolonged QT syndrome usually yields rare interactions based on case reports in the literature. Reading the specific case reports or program results often gives conflicting results and no theoretical basis. This guide allows the reader to look up specific drugs across chapters and read relevant case illustrations. Chapters also include well organized tables showing specific compounds from the drug classes under discusion with the metabolizing sites and inhibitors. These tables are footnoted with whether the inhibitory effects are mild, moderate or potent.
Using the drug metoprolol as an example - the index shows four pages referenced with three of those pages containing the drug in tables. The pages describe that it is hepatically metabolized by 2D6 and 3A4. The authors provide an analysis of pharmacokinetic drug interactions that illustrate what can happen if the enzymes metabolizing metoprolol are affected by other agents.
The title of this book is somewhat of a misnomer. The authors have done an excellent job of balancing the theoretical and practical aspects of drug interaction in a book that is clinically useful. Any physician prescribing multiple medications or single medication to a patient who is already taking several will find this book extremely useful. The level of scholarship in this book is very high and it has a unique niche in the drug interaction literature. If there is a better book out there on drug interactions - I haven't found it. If you have - send the reference to me and I will review it and compare it to this book.
George Dawson, MD
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