Type of bind: Paperback
Dewey Decimal Number: 615.788
EAN num: 9781585620913
ISBN number: 1585620912
Label: American Psychiatric Publishing
Manufacturer: American Psychiatric Publishing
Quantity: 1
Page Count: 313
Printing Date: 2003-05
Publishing house: American Psychiatric Publishing
Sale Popularity Level: 1158069
Studio: American Psychiatric Publishing
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Editor's Notes and Comments:
Product Description:
This remarkable volume of case vignettes was written to complement the principles detailed in the comprehensive work Concise Guide to Drug Interaction Principles for Medical Practice: Cytochrome P450s, UGTs, P-Glycoproteins, Second Edition, published by American Psychiatric Publishing, Ltd. Each case study is thoroughly referenced and depicts real clinical events. Many are direct narrations from patients of the author or his colleagues, with identifiers subtly altered to ensure confidentiality. Others are constructed around well-known, accepted, and multiply-verified interactions.
The introductory chapter reviews core concepts and summarizes the P450 system, phase II glucuronidation and P-glycoproteins, enabling the P450 neophyte to 'dive right in' and begin reading the cases. Subsequent chapters are organized by the nature of the metabolic processes that account for the depicted drug interaction:
- 2D6 case vignettes, 3A4 case vignettes, 1A2 and complex clozapine/olanzapine case vignettes, and 2C9/2C19/2E1/2B6 and complex phenytoin case vignettes. These chapters present drug interaction cases as they relate to specific P450 enzymes
- Complex P450 case vignettes, in which more than one P450 enzyme is significantly involved or the P450 influences are dominant in the presence of both P450 and non-P450 influences
- Non-P450 case vignettes, in which the principal mode of drug interaction involves the P-glycoprotein transporter, phase II glucuronidation, or some other non-P450 pharmacokinetic issue, or cases in which the fundamental interaction is pharmacodynamic rather than pharmacokinetic
At the end of this volume is a revealing self-assessment test case so readers can evaluate their progress in becoming drug interaction detectives.
Thoroughly indexed and referenced, with appendices of tables for quick reference to the P450 system, UGTs, and P-glycoproteins, the case vignettes in this exceptional work illustrate interactions with both psychoactive agents and drugs from other branches of medicine.
As such, this essential companion to more in-depth analyses of the P450 system will find an immediate audience among not only psychiatrists but also a wide range of medical specialists and generalists, as well as those who are in any way acquainted with the mental health field.
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You cannot call yourself a Psychopharmacologist, or even a modern Psychiatrist if you are not practicing with an understanding of P450 and how this is affecting your patient. Ever wondered why your patient is having unexpected reactions to the addition or subtraction of medications, or perhaps why the antidepressant you selected isn't working or why the mood stabilizer levels aren't adding up? Quite simply the liver makes enzymes that are having an effect on your medications, particularly in combinations of medications. You need to know who is doing what to whom and why and this book will explain that. This book is the result of an accumulation of much tedious scientific data transformed by this well-respected psychiatrist into pleasing vingnettes which you can translate into practice.
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